Cdp choline reddit. Learn more about Citicoline uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Citicoline. I recently saw a study suggesting that there is an increased stroke risk with long term use. I suppose some could counteract the depressive effects of the Alpha GPC with theanine but it hasn't worked for me. Most painless way to get off nicotine would probably be cytisine (tabex). Citicoline, also known as CDP-Choline, functions as an essential intermediate in the synthesis of phospholipids and cell membrane components. It also gives me a massive erection, but what good is that if I want to fall asleep haha. Background Adequate intake of choline is essential for growth and homeostasis, but its supply does often not meet requirements. I am considering taking a choline supplement for cognition and have researched both alpha gpc and cdp choline. I'd more or less expect supplemental choline, regardless of the form, to give you similar side effects more or less. My suggestions for most ppl would be: CDP-Citicoline is probably the most expensive choline source, so if you just want a straight (but highly effective) choline source go with Alpha-GPC. Otherwise it may actually make your lethargy worse and cause depression. I would go for Citicoline just because it also gives you I love CDP choline. gov/pubmed/805198 Citicoline (INN), also known as cytidine diphosphate-choline (CDP-choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. true Thank goodness for reddit! I had been feeling suicidal after taking phosphadityl choline in a large dose for several weeks. I like CDP choline more than Alpha-GPC, simply because CDP choline essentially works like a two-in-one nootropic, whereas Alpha-GPC is basically just choline. Dosage, side effects included. What are the things one should know while taking or before starting Citicoline (CDP-Choline)? Please share anything you would like a newbie to know, anything obvious too, please. Does anyone take CDP-choline or Alpha-GPC daily or most days? I'm curious if the accumulative depressive effects of extra choline are universal, or if some people benefit from continuous choline boosting. 2g Omega-3 2x Day5k IU Vitamin D Every Other Day1000mg Ester-C 1x Morning400mg SAMe 1x Morning750mg Glucosamine 2x Day750mg MSM 2x Day150mg Wellbutrin XL 1x Morning CDP Choline is often felt to be slightly depressive, so best just before bed. Meaning that choline is converted and released faster than the 72 hours that the lower content CDP choline is released. " CDP-Choline from nootropics depot causing extreme brain fog? I was taking it with piracetam and it made me feel like I had Alzheimer's (only had <500 mg per day over the course of several weeks). Any thoughts? Current Regimen:Centrum Multi 1x Morning 2. Choline Bitartate and Choline Citrate are economic forms of Choline. Also CDP choline slightly boosts up Dopamine, Serotonin, and Norepinephrine which people with ADHD also lack. So anyway, I've found that combining sunflower lecithin with CDP choline has wonderful effects on mood either alone or as part of a nootropic stack. So I had an idea, combining both Alpha GPC and CDP Choline. Discover what is CDP Choline (Citicoline), the correct dosages, popular stacks, and benefits if you supplement it. Luckily, the lack of clinical benefits obtained with choline or lecithin are not shared by other phospholipids involved in choline biosynthetic pathways, including GPC and citicoline (cytidine 5′-diphosphocholine, also known as CDP-choline), which are able to increase ACh content and release (44, 46). But the differences in feeling between CDP and alpha GPC are even more subtle than that. CDP Coline breaks down into choline and Cytidine in the body. 17 votes, 18 comments. Choline should help with nicotine withdrawal, but only if you're deficient. I use it and sometimes there is a mild increase in anxiety, but nothing how you described. Do you fet the same side effects from choline you get in your diet? CDP-choline is the direct precursor to phosphatidylcholine, though I seem to recall that the body breaks oral CDP-choline it into cytidine and choline before absorption. This is of particular clinical importance in preterm infants and cystic fibrosis patients. nlm. 2g of piracetam. Thank for any input Archived post. A handful of people however, experience spikes in symptoms of depression and anxiety, and increased difficulty in focusing. My experience with nootropics has been very hit or miss, as I'm sure is true of most here. CDP Choline so far has worked the best for me, because there is a much lower dosage available compared to the other two I mentioned. Choline has differing effects on different people--most people say that moderate supplementing choline helps in some way or another with their symptoms of depression and anxiety, as well as focus. Which one has better benefits for brain health and cognition? Full review of Citicoline, a Naturally occurring choline source that is used to treat patients with CV disorders. Choline deficiency decreases phosphatidylcholine (PC) and betaine synthesis, resulting in organ pathology, especially of liver, lung, and brain. its really good for memory and energy too. CDP-Choline (Citicoline) is known to increase cognition and brain function, improve focus and motivation, and reduce fatigue Choline side effects and deficiency symptoms explained: learn signs of low choline, possible side effects from high doses or supplements, and safe-use tips. true been taking CDP choline for 3-4 years. I feel more confident and able to focus on what needs to be said/done rather than the aching in pain. CDP choline gave me terrible neck cramps, in the back of my neck. Aniracetam – releases more acetylcholine (ACh) 2. https://www. Citicoline (CDP Choline) 20% Choline and 50% Cytidine by weight, Cytidine is a precursor of Uridine. 4g Piracitam 2x Day1. 96 votes, 118 comments. There are a lot of moving parts here: we need to take into account that the choline content of CDP is 18. Sep 7, 2024 · This is to help reduce spamming in the subreddit; if you wish to discuss your brand name supplement, simply list the ingredients and dosages, not the brand name. However, I do plan to introduce choline supplements into my stack and see how I feel on it using Leo's protocol (1g of CDP choline + phosphatidylcholine daily, 100-300mg Alpha GPC when needed for acute effects, 100mg of UMP during Alpha GPC dosage) This may be too much cholinergic signaling who knows I have also seen some reddit posts warning of CDP-Choline half life leading to build up and worse depression/fog but I haven't seen a single study or authoritative looking source warning of tis. This elevation depends on the type of bacteria you have. Aug 28, 2025 · Cytidinediphosphocholine (CDP-choline; citicoline) is a nootropic compound that converts to both choline and cytidine upon ingestion, the latter of which converts into uridine in the body. I need it to consistently get benefits from piracetam or noopept and to be able to think clearly all day without tiring. I took a break from it Sunday and had a bad headache, body aches, and brain fog on Monday. Following as I started cdp choline 2 weeks ago taking 500mg split during the day (along with 30 mg Noopept and 30mg Vyvanse). Citicoline supplementation increases levels of vital neurotransmitters like acetylcholine and dopamine, supporting cognitive function, learning, and memory formation. Would taking both be safe or ideal at all? Highly, unlikely that it was choline related. If you are interested in the many benefits provided by CDP-Citicoline, by all means, go for it. It got so bad that I quit but I still feel sore. "CDP Choline lasts in the body for 3 days: Taking CDP Choline requires a bit of forward thinking because it has a half-life of 3 days. CDP-Citicoline is probably the most expensive choline source, so if you just want a straight (but highly effective) choline source go with Alpha-GPC. A naturopathic doctor's guide to choosing the most effective choline for your health goals. Cytidine is further converted into Uridine which helps in converting the choline into Acetylcholine. My Final Thoughts on Alpha-GPC and CDP-Choline As we wrap up this discussion on Alpha-GPC and CDP Choline (Citicoline), it's important to acknowledge that both these choline-containing compounds have distinct strengths that can serve specific needs in the field of cognitive enhancement and neuroprotection. Raising choline level primarily in brain vs body - CDP-Choline provides the uridine needed for phosphatidylcholine synthesis. How is this possible? Can acetylcholine overloads cause this? But in general if I say, there will be an increase in dopamine due to the improvement in better memory recall from choline, leading to hopefully, better decision making and consequently increase in dopamine. Alpha-GPC supplies a higher concentration of choline than CDP choline (or citicoline); however, CDP choline supplies both choline and cytidine, which converts to uridine. CDP is only a small amount of choline (around 18% if I remember correctly), so its hard to think that would of caused such a dramatic increase in acetylcholine - but it can happen to those who are sensitive to acetylcholine. Coluracetam – increases choline – ACh conversion through the High Affinity Choline Uptake (HACU) Jul 31, 2014 · CDP choline makes me really tired for some reason which is why I mention taking it before bed. It felt like I was straining all day. And congrats on finally finding something that works for you! I might try incorporating more choline-rich foods more regularly into my diet and see if that makes a difference. It seems to be there is a 70 hour half life for choline, so I hope I Cdp choline and alpha gpc choline are just different forms of choline. Alpha GPC give a bit more bang for the buck in a sense for choline per $, so might be the best starting point. It's bioavailability sucks, Alpha-GPC would give you way more bioavailability per mg. Do you take the choline in the AM or PM? Learn more about Citicoline uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Citicoline. I've been reading that they both react differently compared to one another. We compared four different . Supplements) submitted 6 months ago by Sauronek89 Does ALCAR cause choline depression like CDP-Choline? Alpha-GPC 40% Choline by weight. I am aware that CDP contains uridine and a smaller concentration of Choline but I'm more interested in the brain fog/memory/focusing effect of the supplements. I know it is the choline because when I stopped taking it I felt normal again. CDP choline seems to mitigate the effects I feel when I've got extremely low amount of dopamine activity and high amounts of cortisol. This is the ultimate guide to CDP-choline. CDP Choline may help with Alzheimers and Mast Cell - histamine issues. Cdp choline is good by itself, alpha gpc is a good wingman if you are already taking some type of choline. That said, it is a source of both nutrients needed to create this precursor. New comments cannot be posted and votes cannot be cast. If you take choline bitartrate for example, your body has to convert it to Phosphatidylcholine Nicotine up regulates choline and dopamine transmission. Does ALCAR cause choline depression like CDP-Choline? (self. This is really interesting, thanks for sharing your experience. nih. Now the difference between something like piracetam and coluracetam or phenylpiracetam are going to be more apparent. 5%, we need to know the half-life of choline (3 days), and we need to be good at maths. I take it every other day because if I take it every day I start to get slightly depressed and have an existential crisis. I never exceed 250mg and most days I take about 100-200mg with about 2. Your not wasting your time, choline bitartrate works great, but like most people mentioned it also elevates TMAO, which is not a good thing. I thought it may be my allergy meds causing me to feel like this, but I knew it was something I was taking. Research safe cholinergics and verify with Reddit experience stories and pub med, CDP choline is the preferred route, add something that upregulates dopamine; for example a natural MAOI like rhodiola crenulata (stimulant properties needs to be cycled 8-12 weeks). If you use any of the racetam-family of nootropics in your stack, you likely should add a choline supplement. This is a subreddit designed for supplements, so obviously most users will be biased for supplements. I did some other research and have stopped now for about 36 hours. I notice that CDP gives me more depressive feelings than an equal amount of GPC, but other than that they "feel" pretty much the same. ncbi. I can only imagine CDP choline being good in cases of severe deficiency (to where it gives you migraines) or some genetic issue processing ACh. CDP choline is good for ADHD symptoms in low doses if I take too much i get muscle twitches and brain fog. This started after about 2 weeks but I felt great otherwise. 4g-3. Compare Alpha-GPC, CDP-choline, and phosphatidylcholine supplements. Alpha GPC will have more immediate effects than CDP choline and as you’ve stated alpha gpc is a 4-6hr half life. CDP Choline Making Me Tired? - posted in Brain Health: I was taking 250mg CDP 2x a day and have noticed brain fog/tiredness. CDP-choline is a superior form of supplementary choline, though personally I'd just eat eggs. You will learn about its benefits, side effects, how much to take, the best time to take it, and much more! Two of the most popular choline supplements are Alpha-GPC and CDP Choline. 1. Because the racetamsall affect choline and/or acetylcholine use in your brain in some way. Also most people seem to take 150-300-600mg of alpha gpc than the 250-500mg cdp choline which I see. gpzo, uqzc, zfjezt, hkk3, gbme, opodan, mplg, jxnjh, u8jq, dpmnhm,